The 12.45pm BST kick-off will be the ninth time in history the sides have met in the world's oldest cup competition.
Here, we recap all previous FA Cup meetings between the two clubs to date...
February 1956, fifth round - Manchester City 0-0 Liverpool
The first ever FA Cup tie between the two sides ended in a goalless draw at Maine Road.
Don Welsh's Reds featured the legendary Billy Liddell, Ronnie Moran and Alan A'Court.
Liddell found the net in the first half, but the goal was chalked off due to a reportedly questionable offside call, forcing a replay at Anfield.
February 1956, fifth-round replay - Liverpool 1-2 Manchester City
Four days later, Liverpool were hopeful they could capitalise on their home advantage.
Alan Arnell scored the Reds' opener seven minutes into the second half and things were on track.
The visitors equalised through Jack Dyson, however, and then a last-minute winner from Joe Hayes secured their spot in the quarter-finals.
February 1973, fourth round - Liverpool 0-0 Manchester City
Bill Shankly's side needed a replay against Burnley at Anfield to progress in the previous round.
In similar fashion to 1956, the two teams couldn't be separated and the game ended 0-0, with Liverpool needing to go to Maine Road and get a result if they were to advance.
February 1973, fourth-round replay - Manchester City 2-0 Liverpool
Colin Bell pounced on the rebound of an excellent Ray Clemence save to give City a lead in the 13th minute.
Six minutes into the second half, a scramble in the six-yard box saw the ball fall to Tommy Booth, who doubled the lead and gave the Reds a mountain to climb.
Liverpool were unable to do so and their wait for a first FA Cup victory at Maine Road continued.
March 1988, quarter-final - Manchester City 0-4 Liverpool
In what was a dominant display for Liverpool, a piece of John Barnes magic on the left wing set up Ray Houghton to score an impressive volley in the top left corner.
Peter Beardsley doubled the Reds' lead from the penalty spot, blasting beyond Mike Stowell.
Goals from Craig Johnston and Barnes in the final 15 minutes wrapped up a place in the last four and with it an emphatic victory - and a historic one at that at Maine Road.
February 2001, fifth round - Liverpool 4-2 Manchester City
Gerard Houllier's men took a comfortable 2-0 lead in the opening 12 minutes of this tie thanks to Jari Litmanen's penalty and well-taken Emile Heskey effort.
Although Andrei Kanchelskis pulled one back for the visitors, the two-goal cushion was later restored by Vladimir Smicer's spot-kick.
Markus Babbel then headed home the fourth goal, before Shaun Goater added a late consolation for the visitors, with Liverpool going on to lift the trophy as part of an historic treble-winning campaign.
