Palace confirmed a place in the last four after seeing off Fiorentina 2-4 on aggregate following Thursday night's second leg in Italy.
Shakhtar Donetsk, who also had a 3-0 lead from the first leg, confirmed their place in the semis after knocking out AZ Alkmaar. The Ukrainian side secured a 2-2 in the second leg in the Netherlands, to progress 5-2 on aggregate.
The first leg of the semi-final will take place away from home at the Henryk-Reyman-Stadium, where Shakhtar have played their home European ties throughout 2025/26. Kick-off is set for 20:00 BST (21:00 local time) on Thursday, 30th April.
The return leg at Selhurst Park will take place on Thursday, 7th May, once again kicking off at 20:00 BST. The winners of the tie between the FA Cup and Ukrainian Cup holders will advance to the final in Leipzig on Wednesday, 27th May.
